On Optimality of Stepdown and Stepup Multiple Test Procedures

Consider the multiple testing problem of testing k null hypotheses, where the unknown family of distributions is assumed to satisfy a certain monotonicity assumption. Attention is restricted to procedures that control the familywise error rate in the strong sense and which satisfy a monotonicity condition. Under these assumptions, we prove certain maximin optimality results for some well-known stepdown and stepup procedures.Comment: Published at http://dx.doi.org/10.1214/009053605000000066 in the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org

Distributed Control System for Turbine Engines

A distributed control system (DCS) for a turbine engine has been demonstrated an

Distribution of Breeding Ducks Relative to Habitat Characteristics in the Prairie Pothole Region of North Central Montana

Continental waterfowl population declines in the early 1980s led to the development and implementation of the North American Waterfowl Management Plan.  The plan identified wetland and grassland losses in the Prairie Pothole Region (PPR) of Canada and the United States as the major causes of low continental duck populations.  Until 2008, north central Montana was the only remaining PPR area in the United States without a ground-based annual survey to monitor breeding duck populations and quantify breeding duck habitat.  The purpose of this study was to establish an annual breeding duck survey in north central Montana to 1) develop species-specific breeding pair predictive models, and 2) apply the models to estimate the distribution of breeding ducks and identify priority areas for conservation.  We observed 10539 indicated breeding duck pairs on approximately 675 wetland basins surveyed annually from 2008-2014.  A competing models analysis was used to identify local- and landscape-scale habitat characteristics to predict breeding duck pair abundance on wetland basins.  The five most commonly observed species were modeled separately; those species were mallard (Anas platyrhynchos), northern pintail (A. acuta), gadwall (A. strepera ), northern shoveler (A. clypeata) and blue-winged teal (A. discors).  At the local scale, wetland basin area, the square root transformation of wetland basin area, and wetland basin class were important predictors for all species.  Important model predictors varied by species at the landscape scale.  We applied the models in a GIS to develop a decision support tool for conservation actions funded by the Migratory Bird Conservation Fund

Saturn 5/Skylab multiple-protuberance heat transfer test data analysis

Analysis of heat transfer data obtained during Saturn 5/Skylab multiple protuberance heat transfer tes

Functional Differences between the N-Terminal Domains of Mouse and Human Myosin Binding Protein-C

The N-terminus of cMyBP-C can activate actomyosin interactions in the absence of Ca2+, but it is unclear which domains are necessary. Prior studies suggested that the Pro-Ala rich region of human cMyBP-C activated force in permeabilized human cardiomyocytes, whereas the C1 and M-domains of mouse cMyBP-C activated force in permeabilized rat cardiac trabeculae. Because the amino acid sequence of the P/A region differs between human and mouse cMyBP-C isoforms (46% identity), we investigated whether species-specific differences in the P/A region could account for differences in activating effects. Using chimeric fusion proteins containing combinations of human and mouse C0, Pro-Ala, and C1 domains, we demonstrate here that the human P/A and C1 domains activate actomyosin interactions, whereas the same regions of mouse cMyBP-C are less effective. These results suggest that species-specific differences between homologous cMyBP-C isoforms confer differential effects that could fine-tune cMyBP-C function in hearts of different species

Energy efficient engine. High pressure compressor detail design report

A compressor optimization study defined a 10-stage configuration with a 22.6:1 pressure ratio, and adiabatic efficiency goal of 86.1%, and a polytropic efficiency of 90.6%; the corrected airflow is 53.5 kg/sec. Subsequent component testing included three full-scale tests: a six-stage rig test, and another 10-stage rig test completed in the second quarter of 1982. Information from these tests is being used to select the configuration for a core engine test scheduled for July 1982 and an integrated core/low spool test slated for early 1983. The test results will also provide data base for the flight propulsion system

Irreversibility and Polymer Adsorption

Physisorption or chemisorption from dilute polymer solutions often entails irreversible polymer-surface bonding. We present a theory of the non-equilibrium layers which result. While the density profile and loop distribution are the same as for equilibrium layers, the final layer comprises a tightly bound inner part plus an outer part whose chains make only fN surface contacts where N is chain length. The contact fractions f follow a broad distribution, P(f) ~ f^{-4/5}, in rather close agreement with strong physisorption experiments [H. M. Schneider et al, Langmuir v.12, p.994 (1996)].Comment: 4 pages, submitted to Phys. Rev. Let

Calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis: a rapid method to evaluate inhibitors of arachidonic acid metabolism in vivo

The present investigation characterizes calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis in the rat. Intraperitoneal injection of A-23187 (20 μg/rat) stimulated marked biosynthesis of 6-keto-PGF1α (6-KPA), TxB2, LTC4 and LTB4, with no detectable changes on levels of PGE2. Levels of all eicosanoids decreased rapidly after a peak which was seen as early as 5 min. Enzyme markers of cellular contents of neutrophils and mononuclear cells, MPO and NAG respectively, decreased rapidly after ionophore injection; this was followed by increases after 60 min. Indomethacin, a selective cyclooxygenase inhibitor, and zileuton and ICI D-2138, two selective 5-lipoxygenase inhibitors attenuated prostaglandin and leukotriene pathways respectively. Oral administration of zileuton (20 mg/kg, p.o.) inhibited LTB4 biosynthesis for up to 6 h suggesting a long duration of pharmacological activity in the rats consistent with its longer half-life. The rapid onset and the magnitude of increases in levels of eicosanoids render the ionophore induced peritoneal eicosanoid biosynthesis a useful model to evaluate pharmacological profiles of inhibitors of eicosanoid pathways in vivo

Establishing endangered species recovery criteria using predictive simulation modeling

Listing a species under the Endangered Species Act (ESA) and developing a recovery plan requires U.S. Fish and Wildlife Service to establish specific and measurable criteria for delisting. Generally, species are listed because they face (or are perceived to face) elevated risk of extinction due to issues such as habitat loss, invasive species, or other factors. Recovery plans identify recovery criteria that reduce extinction risk to an acceptable level. It logically follows that the recovery criteria, the defined conditions for removing a species from ESA protections, need to be closely related to extinction risk. Extinction probability is a population parameter estimated with a model that uses current demographic information to project the population into the future over a number of replicates, calculating the proportion of replicated populations that go extinct. We simulated extinction probabilities of piping plovers in the Great Plains and estimated the relationship between extinction probability and various demographic parameters. We tested the fit of regression models linking initial abundance, productivity, or population growth rate to extinction risk, and then, using the regression parameter estimates, determined the conditions required to reduce extinction probability to some pre-defined acceptable threshold. Binomial regression models with mean population growth rate and the natural log of initial abundance were the best predictors of extinction probability 50 years into the future. For example, based on our regression models, an initial abundance of approximately 2400 females with an expected mean population growth rate of 1.0 will limit extinction risk for piping plovers in the Great Plains to less than 0.048. Our method provides a straightforward way of developing specific and measurable recovery criteria linked directly to the core issue of extinction risk